Pregnenolone Benefits, Side Effects, Dosage, and Interactions

Pregnenolone Benefits, Side Effects, Dosage, and Interactions Holistic Health Print The Health Benefits of Pregnenolone The Supplement That Is Promoted for Brain Health By Cathy Wong Medically reviewed by Medically reviewed by Caitilin Kelly, MD on November 24, 2019 Caitilin Kelly, MD, is a clinical physician at  Indiana University  Health Bloomington Hospital and is board-certified in internal medicine. Learn about our Medical Review Board Caitilin Kelly, MD Updated on February 03, 2020 More in Self-Improvement Holistic Health Happiness Meditation Stress Management Spirituality Inspiration Brain Health Technology Relationships View All Pregnenolone is a steroid hormone that plays a key role in the production of other steroid hormones, including progesterone, DHEA, and estrogen. The substance is found naturally in the body, but some people also take it in supplement form to help keep memory sharp through the years. Verywell / Cindy Chung Health Benefits Proponents claim that taking pregnenolone supplements can help to combat age-related memory impairment, as well as protect against a variety of health conditions. In alternative medicine, pregnenolone is said to aid in the treatment of the following health problems: Alzheimers diseaseallergiesarthritisdepressionendometriosisfatiguefibrocystic breast conditionmenopausal symptomsmultiple sclerosispremenstrual syndromepsoriasisscleroderma Pregnenolone is also used to sharpen memory, reduce stress, stimulate the immune system, promote detox, prevent heart disease, and slow the aging process. Although a number of animal and human studies published in the 1940s indicated that pregnenolone may help manage arthritis and reduce stress, more recent research on pregnenolone is fairly limited. However, several studies published in recent years suggest that pregnenolone may offer certain health benefits. Heres a look at some key findings from those studies. Memory Preliminary research shows that pregnenolone may help protect against aging-related memory impairment. In a 2001 report published in Brain Research Reviews, for instance, investigators analyzed the available studies on steroid hormones and their effects on learning and memory in the aging brain. But while research in animals demonstrated that pregnenolone may enhance memory, the reports authors note that human-based studies on pregnenolone and memory have yielded mixed results. Depression Pregnenolone may help alleviate depression, according to an animal-based study published in the Proceedings of the National Academy of Sciences of the United States of America in 2012. In tests on rats, the studys authors determined that pregnenolone may help relieve depression by treating abnormalities in certain components of brain cells. Schizophrenia Pregnenolone shows promise in the treatment of schizophrenia, according to a report published in Neuroscience in 2011. In their analysis of the available research on pregnenolone and schizophrenia (including a number of animal-based studies and several pilot studies in humans), the reports authors found that pregnenolone may benefit schizophrenia patients by affecting steroid compounds in the brain. The report also indicates that pregnenolone may aid in schizophrenia treatment by increasing brain levels of gamma-aminobutyric acid. Possible Side Effects Due to a lack of research, little is known about the safety of long-term or regular use of pregnenolone supplements. However, theres some concern that pregnenolone may trigger a number of side effects, including insomnia, anxiety, mood changes, headache, and irregular heart rhythm. It also has the potential to cause facial hair growth or hair loss. Since pregnenolone can influence hormone levels, avoid using pregnenolone if you have or are at risk for hormone-sensitive conditions (such as breast cancer, prostate cancer, endometriosis, and uterine fibroids). California requires a label regarding a possible risk of promoting hormone-dependent cancers. Dosage and Preparation There is not enough scientific data to provide a recommended dose of pregnenolone. Due to the limited research, its too soon to recommend pregnenolone as a treatment for any condition.  Its also important to note that self-treating a condition and avoiding or delaying standard care may have serious consequences. If youre considering using it for any health purpose, make sure to consult your physician first. Keep in mind that supplements havent been tested for safety and dietary supplements are largely unregulated. In some cases,  the product may deliver doses that differ from the specified amount for each herb. In other cases, the product may be contaminated with other substances such as metals.  Also, the safety of supplements in  pregnant women, nursing mothers, children, and those with medical conditions or who are taking medications has not been established. What to Look For If youre seeking a natural remedy to help preserve memory, some studies show that increasing your intake of antioxidants and omega-3 fatty acids may have memory-enhancing effects. A number of alternative therapies may also aid in the treatment of depression. For example, herbs such as St. Johns wort might help relieve symptoms of depression, while mind-body practices like acupuncture and meditation could help improve mood. Additionally, regular exercise and time spent outdoors have been shown to reduce stress and improve mood.